Dr. Mojibur R. Khan
Research
Microbes of human body are indispensable for maintaining good health. The human gut is colonized by 100 trillion microbes belonging to few thousand species and by their enormous number of genes, they influence the physiology of the host. The gut microbiota is inherited from mother and subsequently modulated by diet, disease, aging, medication etc. Understanding the dynamic nature of the microbiota and its relation to physiology will help us to develop pro- & pre- biotics for targeted modulation for better health. The north-east of India is home to more than 200 distinct tribes with distinct genetic background and diverse food habits is an ideal place to undertake such studies. Our group has undertaken research to determine the gut bacterial profile of the tribal population of north-east of India to understand the genetic, dietary or environmental forces acting in shaping their profile and to explore beneficial gut bacteria in these population.
The key questions of this research are:
- What is the variation and similarity in the gut bacterial profile of the ethnic tribes of north-east of India?
- How is this variation or similarity related to other population of India and the world?
- Are there microbes in this population that are linked to some good or ill health effects?
- How to manipulate the gut bacterial profile for better health
Academic
2003(January) – 2006 (January): PhD
Institution: College of Life Sciences, University College Dublin (UCD), Dublin 4, Ireland.
1999-2001: MSc (Agricultural Biotechnology)
Institution: Assam Agricultural University, Jorhat, Assam, India.
Employments
Associate Professor (II): January 2020- till date
Associate Professor (I): January 2016- December 2019
Assistant Professor (II): August 2011- December 2015.
Institution: Institute of Advance Study in Science and Technology, Guwahati, Assam.
Ramalingaswami Fellow: June 2011- May 2016 (Concurrent).
Institution: Institute of Advance Study in Science and Technology, Guwahati, Assam.
Postdoctoral Scientist: February 2006- May 2011.
Institution: College of Life Sciences, University College Dublin, Dublin 4, Ireland.
Senior Research Fellow: February 2002- October 2002
Institution: Soil Microbiology Laboratory, Assam Agricultural University, Jorhat, Assam, India.
Awards
- UCD Research and Innovation award, 2011.
- Presented the best student oral presentation award in the Society of Irish Plant Pathologists meeting, 2005.
Fellowships
- Energy bioscience overseas fellowship (DBT-ICT centre for bioenergy, Mumbai) (Fellowship offered but declined).
- Ramalingaswami fellowship (DBT, Govt. of India).
- Postdoctoral fellowships (3) from the Department of Agriculture, Food and Fisheries (DAFF, Govt. of Ireland), Enterprise Ireland and Science Foundation Ireland (SFI).
- Department of Agriculture, Food and Fisheries (DAFF, Govt. of Ireland) fellowship during PhD.
- Department of Biotechnology (DBT, Govt. of India) fellowship during MSc.
- University merit scholarship during BSc.
- State merit scholarship during 10+2.
Links
- S Dash, YA Syed, MR Khan (2022) Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders. Frontiers in Cell and Developmental Biology, doi.org/10.3389/fcell.2022.880544 JIF 6.684
- RR Khanikar, M Kalita, P Kalita, B Kashyap, S Das, MR Khan, H Bailung, K Sankaranarayanan (2022) Cold atmospheric pressure plasma for attenuation of SARS-CoV-2 spike protein binding to ACE2 protein and the RNA deactivation. RSC Advances 12 (15), 9466-9472 JIF 3.361
- S Das, MJ Bhattacharjee, AK Mukherjee, MR Khan (2022) Recent advances in understanding of multifaceted changes in the vaginal microenvironment: implications in vaginal health and therapeutics. Critical Reviews in Microbiology, 1-27 org/10.1080/1040841X.2022.2049696 JIF 7.624
- TK Joishy, A Jha, M Oudah, S Das, A Adak, D Deb, MR Khan (2022) Human Gut Microbes Associated with Systolic Blood Pressure. International Journal of Hypertension. https://doi.org/10.1155/2022/2923941 JIF 2.42
- A Kumar, T Joishy, S Das, MC Kalita, AK Mukherjee, MR Khan (2022) A Potential Probiotic Lactobacillus plantarum JBC5 Improves Longevity and Healthy Aging by Modulating Antioxidative, Innate Immunity and Serotonin-Signaling Pathways in Caenorhabditis elegans. Antioxidants 11 (2), 268 JIF 6.313
- Bhuwan Bhaskar, Atanu Adak, Mojibur R Khan (2021) Fractions of traditionally brewed rice beverage relieve anxiety and improve spatial memory in mice. Journal of Ethnic Foods, 8(1): 1-9 JIF 1.37
- Pulipati , P. Sarkar, A. Jakkampudi , V. Kaila, S. Sarkar , M. Unnisa, D. N. Reddy, M. Khan, R.Talukdar (2020) The Indian gut microbiota-Is it unique? Indian Journal of Gastroenterology 39, 133-140 JIF 1.08
- Deb, S. Das, A. Adak, M.R. Khan (2020) Traditional rice beer depletes butyric acid‑producing gut bacteria Faecalibacterium and Roseburia along with fecal butyrate levels in the ethnic groups of Northeast India. 3 Biotech 10, 1-11 JIF 1.798
- A Kumar, A Baruah, M Tomioka, Y Iino, MC Kalita, M. Khan (2020) Caenorhabditis elegans: a model to understand host–microbe interactions. Cellular and Molecular Life Sciences. 77 (7), 1229-1249 JIF 7.014
- K. Joishy, M. Dehingia, M. R. Khan (2019) Bacterial diversity and metabolite profiles of curd prepared by natural fermentation of raw milk and back sloping of boiled milk. World Journal of Microbiology and Biotechnology. 35 (7), 1-12 JIF 2.1
- Das, D. Deb, A. Adak, M. R. Khan (2019) Exploring the microbiota and metabolites of traditional rice beer varieties of Assam and their functionalities. 3 Biotech 9 (5), 1-10 JIF 1.497
- Dehingia, A. Adak, M. R. Khan (2019) Ethnicity-Influenced Microbiota: A Future Healthcare Perspective. Trends in Microbiology. 27 (3), 191-193 JIF 11.776
- Adak, M. R. Khan (2019) A review: an insight into gut microbiota and its functionalities. Cellular and Molecular Life Sciences. 76 (3), 473-493 JIF 6.721
- Dehingia, S. Sen, B. Bhaskar, T. K. Joishy, M. Deka, M. R. Khan (2017) Ethnicity influences gut metabolites and microbiota of the tribes of Assam, India. MEBO-D-17-00014, Metabolomics 2017 13:69 DOI 10.1007/s11306-017-1206-y JIF 3.511
- Sen, M. Dehingia, N. C. Talukdar, M. R. Khan (2017) Chemometric analysis reveals links in the formation of fragrant bio-molecules during agarwood (Aquilaria malaccensis) and fungal interactions. Scientific Reports 2017 7: doi: 10.1038/srep44406. JIF 5.78
- D Gogoi, AJ Choudhury, R Kandimalla, S Kalita, J Kotoky, YB Chaudhari, MR Khan, J Chutia, (2016) Penicillin impregnation on oxygen plasma surface functionalized chitosan/Antheraea assama silk fibroin: Studies of antibacterial activity and antithrombogenic property. Materials Science and Engineering C 60:475-484 JIF 3.09
- M Dehingia, TK Devi, NC Talukdar, R Talukdar, N Reddy, SS Mande, M Deka and MR Khan (2015) Gut bacterial diversity of the tribes of India and comparison with the worldwide data. Scientific Reports doi: 10.1038/srep18563 JIF 5.78
- AJ Choudhury, D Gogoi, J Chutia, R Kandimalla, S Kalita, J Kotoky, YB Chaudhari, MR Khan, K Kalita (2015) Controlled antibiotic-releasing Antheraea assama silk fibroin suture for infection prevention and fast wound healing. Surgery doi:10.1016/j.surg.2015.07.022 JIF 3.38
- S Goyari, SH Devi, B Louis, MR Khan, CK Sharma, MC Kalita, NC Talukdar (2015) Unveiling the optimal parameters for cellulolytic characteristics of Talaromyces verruculosus SGMNPf3 and its secretory enzymes. Journal of Applied Microbiology 119(1):88-98 JIF 2.479
- S Walter, A Kahla, C Arunachalam, A Perochon, MR Khan, S Scofield, and F Doohan (2015) A wheat ABC transporter contributes to both grain formation and mycotoxin tolerance. Journal of experimental Botany doi: 10.1093/jxb/erv048 JIF 5.26
- YB Chaudhari, NC Talukdar, NC Adhikary, MC Kalita, MR Khan (2015) Rice straw based evaluation of lignolytic and cellulolytic capabilities of novel strains of saprophytic fungi from Indo-Burma biodiversity hotspot. Energy & Fuels 29 (2) : 784–792 JIF 2.733
- S Sen, NC Talukdar, MR Khan (2015) A simple metabolite profiling approach reveals critical bio-molecular linkages in fragrant agarwood oil production from Aquilaria malaccensis– a traditional agro-based industry in the north east of India. Current Science 108 (1): 63-71 JIF 0.833
- SN Borah, D Goswami, J Lahkar, HK Sarma, MR Khan, S Deka (2014) Rhamnolipid produced by Pseudomonas aeruginosa SS14 causes complete suppression of wilt by Fusarium oxysporum f. sp. pisi in Pisum sativum. BioControl: DOI 10.1007/s10526-014-9645-0 JIF 2.253
- KI Ansari, SM Doyle, J Kacprzyk, MR Khan, S Walter, JM Brennan, CS Arunachalam, PF McCabe, FM Doohan (2014) Light Influences How the Fungal Toxin Deoxynivalenol Affects Plant Cell Death and Defense Responses. Toxins 6(2), 679-692. JIF 2.13
- SS Ali, LR Gunupuru, GBS Kumar, MR Khan, S Scofield, P Nicholson, FM Doohan (2014) Plant disease resistance is augmented in uzu barley lines modified in the brassinosteroid receptor BRI1. BMC Plant Biology 14(1):227. JIF 4.35
- D Gogoi, D Barman, D Choudhury, M Khan, Y Chaudhari, M Dehingia, AR Pal, H Bailung and J Chutia (2014) Immobilization of trypsin on plasma prepared Ag/PPAni nanocomposite film for efficient digestion of protein. Materials Science and Engineering C 43 237–242. JIF 3.076
- SS Ali, S Kumar, FM Doohan, MR Khan (2013) Brassinosteroid enhances resistance to Fusarium diseases of barley. Phytopathology 103(12):1260-1267. JIF97
- SS Ali, MR Khan, E Mullins and FM Doohan (2013) Identification of Fusarium oxysporum Genes Associated with Lignocellulose Bioconversion Competency. BioEnergy Research 7(1): 110-119. JIF 3.39
- D Gogoi, A J Choudhury, J Chutia, A R Pal, M Khan, M Choudhury, P Pathak, G Das and D S Patil (2013) Development of advanced antimicrobial and sterilized plasma polypropylene grafted muga (Antheraea assama) silk as suture biomaterial. Biopolymers 101 (4):355-365. JIF 2.28
- SS Ali, MR Khan, E Mullins and FM Doohan (2012) The effect of wheat genotype on bioethanol production from straw and the implications for multifunctional crop breeding. Biomass and Bioenergy 42:1-9. JIF 3.41
- SS Ali, MR Khan, B Fagan, E Mullins and FM Doohan (2012) Exploiting the inter-strain divergence of Fusarium oxysporum for microbial bioprocessing of lignocellulose to bioethanol. AMB Express 2(16) DOI: 10.1186/2191-0855-2-16. JIF 2.49
- E Smyth, R Nevin, J McCarthy, MR Khan, M Dow, F O’Gara, and FM Doohan (2011) In vitro analyses are not reliable predictors of the plant growth promotion capability of bacteria; a Pseudomonas fluorescens strain that promotes the growth and yield of wheat. Journal of Applied Microbiology 111: 683-692 JIF 2.38
- C Petti, MR Khan and FM Doohan (2010) Lipid transfer proteins and protease inhibitors as key factors in the priming of barley responses to Fusarium head blight disease by a biocontrol strain of Pseudomonas fluorescens. Functional and Integrative Genomics 10(4):619-27. JIF 2.69
- MR Khan, E O’Brien, BF Carney, and FM Doohan (2010) A fluorescent pseudomonad shows potential for the control of net blotch disease of barley. Biological Control 54(1): 41-45 JIF 1.87
- MR Khan and FM Doohan (2009) Bacterium-mediated control of Fusarium head blight disease of wheat and barley and associated mycotoxin contamination of grain. Biological Control 48(1):42-47 JIF 1.87
- MR Khan and FM Doohan (2009) Comparison of the efficacy of chitosan with that of a fluorescent pseudomonad for the control of Fusarium head blight disease of cereals and associated mycotoxin contamination of grain. Biological Control 48(1):48-54 JIF 1.87
- S Walter, JM Brennan, C Arunachalam, KI Ansari, X Hu, MR Khan, F Trognitz, B Trognitz, G Leonard, D Egan and FM Doohan (2008) Components of the gene network associated with genotype-dependent response of wheat to the Fusarium mycotoxin deoxynivalenol. Functional and Integrative Genomics. 8(4):421-427. JIF 2.69.
- S Kildea, V Ransbotyn, MR Khan, B Fagan, L Gerald, E Mullins and FM Doohan (2008) Bacillus megaterium shows potential for the biocontrol of septoria tritici blotch of wheat. Biological Control 47(1): 37-45 JIF 1.87
- C Petti, MR Khan and FM Doohan (2008) Investigating the mechanisms underpinning bacterium-mediated control of FHB disease. Cereal Research Communications 36:689-693. JIF 0.624
- FM Doohan, C Arunachalam, S Jiang, MR Khan, D Egan, G Erard and S Walter (2008) The wheat response to deoxynivalenol: Does maintenance of hormone homeostasis and alleviation of oxidative stress play an important role in toxin tolerance? Cereal Research Communications 36:233-237. JIF 0.624
- MR Khan, S Fischer, D Egan, and FM Doohan (2006) Biological Control of Fusarium Seedling Blight Disease of Wheat and Barley. Phytopathology 96(4): 386-394 JIF 2.97
- D Thakuria, NC Talukdar, C Goswami, S Hazarika, RC Boro and MR Khan (2004) Characterization and screening of bacteria from rhizosphere of rice grown in acidic soils of Assam. Current Science, 86(7): 978-985 JIF 0.833
- MR Khan, NC Talukdar and D Thakuria (2003) Detection of Azospirillum and PSB in rice rhizosphere soil by protein and antibiotic resistance profile and their effect on grain yield of rice. Indian Journal of Biotechnology, 2 (2): 246-250 JIF 0.510
Patents and technologies
- In vitro production of fragrant agarwood compounds: A method of production of fragrant compounds from the callus culture of the plant Aquilaria malaccensis has been developed and a patent has been filed.
Patent: M R Khan, S Sen, N C Talukdar (10-12-2014) A method for in vitro production of fragrant compounds from Aquilaria malaccensis. Patent No 35515
- An improved fermentation technique for production of fragrant agarwood compounds: DBT has funded BIRAC Biotech Ignition Grant (BIG) for commercialization of the technology on aroma production by fermentation of agarwood. The project envisages pre and post proof of concept (POC) of technology for generation of license and/or start-up in line with the Start-up India Programme. Under the BIRAC BIG project a pilot scale solid state fermentation based system is being designed for commercial production of high value agarwood oil to cater to the perfume industry and thereby promote agarwood in Assam.
Patent: M. R. Khan, S. Sen, N. C. Talukdar (09-05-2016) A method for production of fragrant compounds from resinous chips of Aquilaria malaccensis. Patent No. 355518
- A technique of production of rice based beverage of high alcohol content: A fermentation technique for production of beverage with > 20% alcohol from rice has been developed.
Patent filed: M. R. Khan, B. Bhaskar, A. Adak, N. C. Talukdar (23-02-2017) A method of production of rice based beverage with high alcohol content. Patent Application No. 201731006470.
- A technique of production of red wine using black rice: A techniques has been developed to produce antioxidant rich alcoholic beverage resembling red wine. BIRAC has approved a fund under Promoting Academic Research Conversion to Enterprise (PACE) scheme for optimization of the process. The technology has been transferred to a company named ‘Golden beverages’ for commercialization.
Patent filed: M. R. Khan, B. Bhaskar (17-05-2019) Production of antioxidant rich red wine like alcoholic beverage using black rice. Patent Application No. 201931019623
- Khan MR, Joishy TK, Kumar A, Bhattacharjee J, Bhattacharya A, Mukherjee AK (2022) A Method for Preparation of Functional Curd with Anti-ageing property and High Shelf Life. Patent application number: 202231001501
- Khan MR, Das S, Bhattacharjee J, Bhattacharya A, Mukherjee AK (2022) A Method for Preparation of Soy Yoghurt with Improved Shelf Life and Functional Metabolites Pinitol and Myo-Inositol. Application No. 202231004797
- A startup, Gutvicinta has been launched on 1st February 2019 that will provide next generation healthcare services based on microbiome (gutvicinta.com). Official formalities are being carried out now.
Conference publications, book chapters etc > 60
- Heritage food and beverage research programme [Funded by DST under Science for Equity, Empowerment and Development (SEED) scheme, Govt. of India. Total grant is Rs 1332 lakhs] [Involved as Principal Investigator].
- Optimization of method of red wine production using black rice [Funded by Biotechnology Industry Research Assistance Council (BIRAC) under Promoting Academic Research Conversion to Enterprise (PACE) scheme, Govt. of India under unit of excellence programme. Total grant is Rs 36.33 lakhs][Involved as Principal Investigator].
- Effect of traditional dietary habits on human gut microbes: dairy products of Nepali population and traditional rice beer of tribes of Assam on gut bacterial profile [Funded by the Department of Biotechnology (DBT), Govt. of India under unit of excellence programme. Total grant is Rs 133 lakhs][Involved as Principal Investigator].
- Study on intestinal microbiota of ethnically diverse tribal population of India: enhancing our understanding on effect of host genotype, diet and ecology. [Funded by DBT. Total grant is Rs 80 lakhs][Involved as Principal Investigator].
- Institutional biotech hub [Funded by DBT. Total grant is Rs 27 lakhs][Involved as Co-ordinator].
- Exploration of microbial resources of north-east India: generation of metagenomic DNA bank, construction of metagenomic libraries and screening for genes of interest [Funded by DBT. Total grant is Rs 77.11 lakhs][Ramalingaswami fellowship].
Current Members:
PhD Research Scholars:
- Mr. Arun Kumar ( DBT JRF, PhD Student)
- Ms. M. Bidyarani Devi (CSIR JRF, PhD Student)
- Mr. Chingtham Thanil Singh (CSIR-JRF, PhD Student)
- Ms. Somarani Dash (CSIR- UGC JRF, PhD Student)
Project Staff (ST/SC Community Development Project):
- Dr. Maloyjo Joyraj Bhattacharjee (Project Scientist)
- Dr. Sushmita Das (Senior Research Associate)
- Dr. Yunus Sheikh (Senior Research Associate)
- Ms. Tulsi Kumari Joishy (Senior Research Associate)
- Mr. Anupam Bhattacharya (Senior Research Associate)
- Mr. Rashid Habib Abedeen (Laboratory Assistant)
- Mr. Santhousa Boro (Laboratory Assistant)
- Mr. Pranjit Das (Field Worker)
Ex-members
- Dr. Atanu Adak (Research Associate, DBT)
- Dr. Kaushik Bhattacharjee (N-PDF,SERB, DST)
- Dr. Supriyo Sen (DBT-Postdoctoral fellow)
- Dr. Rupamoni Thakur (N-PDF, SERB, DST)
- Dr. Sailendra Goyari (N-PDF, SERB, DST)
- Ms. Jinu Medhi (CSIR JRF , PhD Student)
- Mr. Yogesh B. Chaudhari (PhD student)
- Ms Madhusmita Dehingia (PhD student)
- Ms Priyanka Sarkar (PhD student)
- Ms Rabiya Sultana (PhD student)
- Mr. Santanu Das (PhD Student)
- Mr. Dibyayan Deb (PhD Students)
- Mr. Bhuwan Bhaskar (PhD student)
Interested students with good academic and research record can send their biodata throughout the year for doctoral and postdoctoral positions. Candidates having UGC/CSIR/DBT/ICMR fellowships will get preference.
Contact: mojibur[dot]khan[at]gmail[dot]com